1. Obvious appetite loss: abdominal distention, dyspepsia, sometimes companied by nausea or vomiting;
2. Hidden pain of right upper quadrant: persistant or intermittent pain in hepatic region; sometimes, pain gets worse when changing physical body position;
3. Debilitation, emaciation, fever or edema without knowing the causes;
4. Jaundice, ascites, itch of skin may also appear;
5. Nosebleed or subcutaneous hemorrhage often emerge.

If any symptoms above occur, a patient should go to hospital for examination and diagnosis, so as to have necessary treatment timely.