Targeted gene therapy: A treatment to remove cancer roots Cancer is molecular network disease
Genomic instability not only is the first characteristic of malignant tumor, but also the cause of producing new mutant cell during cell division. It makes the mutant cells traits of different biological feature occur in tumor cells.
Those mutant genes, which are in developed bio-network, have a great quantity and many complicated functions. In a cell, mutant genes mutually intercommunicate with genes/proteins to construct the complex cell-networks, such as signal channel, gene expression regulation network and metabolism network, etc.
The effect to cell-network would be varied to the various statuses of those mutant genes. Meanwhile, different network structures also decide the resists of gene mutation. In this aspect, actually tumor is a disease of molecular network that the abnormality and complexity of molecular network decide the malignant physical sign and individual difference of tumor.
Targeted gene therapy is using corresponding medicines against the specific carcinogenic sites (those sites could be a protein molecule or a genetic segment in tumor cells). The medicine would take effect by specially combining carcinogenic sites after entering human body, thus tumor cells would die specifically without affecting normal cells around. Briefly, targeted gene therapy aims at a specific gene and eliminates it.
Targeted gene therapy is against disease roots: abnormal genes, this is the fundamental solution for cancer.
Targeted gene therapy
Surgical operation would cause trauma and easily evokes postoperatic complication.
It is a toxic therapy with great toxic side effects and would kill both cancer cells and normal cells at the same time.
Targeted gene therapy is accurately focusing on crucial carcinogenetic sites in tumor cells growth (like enzymes, proteins, receptor, etc.) to stop the growing.
1.Obtain remedial gene
2.Choose genetic carrier
3.Choose target cells
5.Choose and identify transducer cell
6.Return to the blood stream
1.Targeted gene therapy features high targeting to concentrate medicines on specific tumor.
2.It keeps relative high concentration of medicine in tumor partly.
3.Drug acting time is delayed.
4.Lethality to tumor cells rose.
5.mplications the patient suffers.
6.Targeted gene therapy gets the characteristics of non-cytotoxic, effective, harmfulness and high tolerance.
7.Medicine combines with routine therapies (like chemotherapy and radiotherapy), can be given separately or jointly, thus better result would be done.